The AD-associated neuroinflammatory biomarkers are divided into (1) enzymes or signal molecules, including 18-kDa transporters (TSPO), monoamine oxidase B (MAO-B), imidazoline binding sites I2 (I2BS), epoxidation enzyme, and arachidonic acid (AA); (2) G protein-coupled receptors, including purine P2X7 and P2Y receptors, and type 2 cannabinoid receptors (CB2R). This evidence concerns the gene TSPO and Alzheimer disease.