Because LAIR2 can bind to both mouse and human collagens but anti-LAIR1 only recognizes human but not mouse LAIR1, it may be easier for the recombinant LAIR2 to achieve the anti-tumor effect in humanized mice (in which both human and mouse collagens and LAIR1 exist) than anti-the LAIR1 blocking antibody. This evidence concerns the gene LAIR1 and neoplasm.