Interestingly, the cuproptosis signature was significantly positively related to major steps of the cancer immunity cycle both in the TCGA-KIRC cohort and the Xiangya-RCC cohort (Figure 4A, Supplementary Tables S7, S8), including release of tumor antigen, recognition of tumor cell by T cell, and recruitment of diverse immune cells (T cell, macrophage, neutrophil, and Th17). This evidence concerns the gene LINC01194 and renal cell carcinoma.