Pro-inflammatory TAMs are recruited by microenvironmental chemokines, such as CCL2, CCL3, CXCL1, CXCL2, CXCL8/IL8, and CXCL14, to tumor tissues, and produce pro-inflammatory and pro-angiogenic molecules, such as cyclooxygenases (COXs), IL1β, IL6, VEGF and FGF, for promoting tumor progression and metastasis in there (103). This evidence concerns the gene CXCL2 and neoplasm.