Mast cells are recruited by the microenvironmental chemokines, such as CCL2, CXCL1, CXCL8/IL8, and CXCL10, to tumor tissues, and are activated by pro-inflammatory cytokines, such as stem cell facto (SCF), IL33, PGE2, leukotriene B4, and osteopontin, in there (157). Here, SPP1 is linked to neoplasm.