Mast cells have pre-formed secretory granules containing classical and non-classical pro-inflammatory molecules, such as histamines, tryptase, chymase, heparin, lysosomal enzymes, and pro-inflammatory cytokines, such as IL6, IL8, TNFα, VEGF, FGF2, and platelet-derived growth factor (PDGF) (155), and are widely known to play a central role in inflammatory pathogenesis, particularly of allergy and cancer (156). This evidence concerns the gene IL6 and allergic disease.