The activated MSCs become to promote tumor progression and metastasis directly and indirectly through creating immune tolerant environment by producing numerous immunomodulatory molecules, such as TGFβ, PGE2, VEGF, TNFα, IDO, IL1β, IL6, FSTL1, HO1, and soluble HLA-G5 (125). This evidence concerns the gene TNF and neoplasm.