CXCL12 and neoplasm: MSCs highly express various chemokine receptors, such as CCR2, CCR3, CXCR4 and CXCR5, and various metalloproteinases, such as MMP1/2/4/13/14 and tissue inhibitors of metalloproteinases (TIMP1/2), and thus promptly migrate into tumor sites in response to chemokines, such as CCL2, RANTES/CCL5, CXCL12, and CXCL16, within the tumor milieu (124).