In CRC, CAFs produce M-CSF that stimulates CD163+ Møs to produce CCL2, HGF, IL6, and CXCL8/IL8 for recruitment and differentiation of monocytes into immunosuppressive Møs like M2-Møs in normal colon, potentially leading to tumorigenesis (126). This evidence concerns the gene IL6 and colorectal carcinoma.