Myeloid cells produce a variety of pro-inflammatory molecules, such as cyclooxygenases (COXs), prostanoids, arginase 1, TNFα, IL1β, IL4, IL6, IL10 and IL13, and greatly affect multiple steps of tumor evolution, including genomic instability, metabolic reprograming, stromagenesis, angiogenesis, invasion, dissemination, and modification of host immunity (129). This evidence concerns the gene TNF and neoplasm.