Tumor-associate neutrophils, called “TANs”, are generated by various cytokines within the tumor milieu, and become to produce a variety of cytokines, such as TNFα, VEGF, and MMPs, and chemokines, such as CXCL1, CXCL2, and CXCL8/IL8, for promoting tumor growth and metastasis, angiogenesis, inflammation, and immunosuppression (138). This evidence concerns the gene VEGFA and neoplasm.