Basophils have pre-formed secretory granules containing pro-inflammatory cytokines, such as IL4, IL6, IL13, TSLP, GM-CSF and VEGF, and chemokines, such as CCL3, CCL4, CCL5 and CXCL8/IL8, in addition to histamine and granzyme B, and are widely known as a key player in allergy and parasitic infection (167). The gene discussed is IL6; the disease is allergic disease.