Another is an anti-tumor type that produces the unique acidophilic secondary granules composed of major basic protein 1 and 2 (MBP1, MBP2) and a matrix composed of eosinophil cationic protein (ECP), eosinophil-derived neurotoxin (EDN), and eosinophil peroxidase (EPO), and many immunomodulatory molecules (granzyme A, TNFα, IL18, IFNγ, CCL5, CXCL9, CXCL10, etc.). Here, TNF is linked to neoplasm.