DSG1 and acquired polycythemia vera: A number of groups have detected non-Dsg antibodies in the serum of PV patients including those directed against acetylcholine receptors, desmocollin, and mitochondria (9, 39, 44, 46, 47) that may provide an explanation of as to why patients with non-detectable anti-Dsg antibodies can nonetheless present in an active state of disease.