DSG3 and acquired polycythemia vera: Surprisingly, we found that for active PV patients visits (n=159), over 50% of the subjects displayed lesion morphology and corresponding anti-Dsg3 and -1 profiles that contradict the postulates of the DCH regardless of the cut-off value for antibody positivity chosen (ranging from 52.83% for the lowest cut-off of 10IU/ml to 54.72% for the cut-off of 36/37 IU/ml currently suggested by the manufacturer) (Figure 1A).