In the literature, several roles have been reported for AMPs in periodontal disease, such as inhibiting the growth of pathogenic bacteria (LL37, HBD-1, HBD-2, HBD-3, histatin-2, HNP1, HNP2, HNP3), promoting periodontal tissue healing (LL37, HBD-1, HBD-2, HBD-3, histatin-2), promoting bone healing (HBD-2, histatin-1), and serving as a potential indicator of the severity of periodontal disease (HBD-2, HNP1, HNP2, HNP3). This evidence concerns the gene DEFA3 and periodontal disorder.