We found no significant difference in the number of clonotypes between healthy kidney tissue and early DN (Control vs. Early DN p>0.1, Wilcoxon Test; BCR repertoire on the left, TCR repertoire on the right), but the number of clonotypes in advanced DN was significantly different from those in early and Control (Figures 1A, S1A; Advanced DN vs. Control p<0.05; Advanced DN vs. Early DN p<0.05; BCR repertoire on the left, TCR repertoire on the right). Here, BCR is linked to liver dysplastic nodule.