In addition, TILs infiltration calculated using ssGSEA algorithm were generally negative correlated with our signature both in TCGA-BLCA (Figure 4B, Table S5) and Xiangya cohort (Figure 4C, Table S5) including activated CD4+ T cell, CD8+ T cell, DCs and NK cells. The gene discussed is CD4; the disease is bladder transitional cell carcinoma.