Furthermore, vitamin D deficiency is described in the pathophysiology of Th2-driven allergic diseases such as asthma, in which the lower hormone levels are associated with IL-4, IL-5, IL-9, and IL-13 deregulation, increase in asthma markers (IgE and eosinophil), and more severe clinical disease manifestation, as reported (146–149). This evidence concerns the gene IL5 and asthma.