To further explore the mechanism by which TCF1 regulates CLL prognosis and the partner molecules interacting with TCF1, functional and pathway enrichment analysis revealed that TCF1 is positively correlated with BCL11B, which is mainly involved in T cell differentiation and activation and immune regulation in CLL patients, in accordance with the literature (20, 22). This evidence concerns the gene TCF7 and B-cell chronic lymphocytic leukemia.