Downregulation of TCF1 and BCL11B, particularly in CD8+ T cells, in CLL patients may impair the stem-like differentiation potential of memory CD8+ T cells, leading to T cell immune dysfunction, and this may provide insight into the mechanism by which TCF1 and BCL11B regulates the prognosis of CLL patients. Here, CD8A is linked to B-cell chronic lymphocytic leukemia.