The results demonstrated that the percentages of TCF1+ cells in the CD3+, CD3+CD4+, and CD3+CD8+ T cell populations from CLL patients were significantly lower than that in corresponding T cell subgroups from HIs (P values are 0.004, < 0.001 and < 0.001, respectively), particularly for CD3+CD8+ T cells (Figures 6B, C). This evidence concerns the gene CD8A and B-cell chronic lymphocytic leukemia.