Amazingly, TCF1 had low expression not only in PBMCs as determined by qPCR (P = 0.011; Figure 2C) but also in CD3+ T cells as determined by FCM (P = 0.004; Figure 2D) in CLL patients compared with HIs, which is highly consistent with the above findings from the GEO databases. This evidence concerns the gene TCF7 and B-cell chronic lymphocytic leukemia.