On the other hand, the enhanced liver fibrosis (ELF) score, composed of tissue inhibitor of metalloproteinases 1 (TIMP-1), procollagen type III amino-terminal propeptide (PIIINP) and hyaluronic acid (HA), has been evaluated in different studies as a marker for different stages of fibrosis in liver disease. This evidence concerns the gene TIMP1 and Hepatic fibrosis.