As shown by Zhang et al., in a study on the influence of different monocyte subpopulations in NAFLD, they found that an elevated fraction of intermediate monocytes (CD14++CD16+) in peripheral blood, as well as a reduced fraction of classical monocytes (CD14++CD16-), was closely related to the development of liver disease (81). The gene discussed is CD14; the disease is metabolic dysfunction-associated steatotic liver disease.