High levels of serum IL-18 levels were reported in patients with systemic juvenile idiopathic arthritis (s-JIA) (16–25) and its adult homolog adult Still’s disease (AOSD) (26–30), as well as various other inflammatory diseases including systemic lupus erythematosus (50) and Crohn’s disease (51). This evidence concerns the gene IL18 and systemic lupus erythematosus.