Laboratory findings show neutrophilia, thrombocytosis, hyperferritinemia, and increased levels of inflammation markers such as C reactive protein and serum amyloid A. Recent studies revealed proinflammatory cytokines of the innate immune system, especially, IL-1, IL-6, and IL-18 play an important role in the pathogenesis of s-JIA and AOSD (52). This evidence concerns the gene IL18 and juvenile idiopathic arthritis.