The multivariate analysis demonstrated that BMI < 18.5 (OR = 2.100, CI = 1.216–3.626), poorly differentiated (OR = 4.885, CI = 2.627–9.085), larger tumor size (OR = 1.240, CI = 1.169–1.316), higher CEA (OR = 1.447, CI = 1.046–2.002), higher CA19-9 (OR = 1.529, CI = 1.151–2.029) were associated with a higher risk of LNM. This evidence concerns the gene CEACAM5 and neoplasm.