As depicted in Figure 1A, The results show that the model demonstrated good resolution with an area under the curve (AUC) of 0.716 (95% CI: 0.683–0.748) in the training cohort, the AUC value of tumor size was 0.682 (95% CI: 0.647–0.716) which was significantly higher than other risk factors (BMI, 0.456; histological grade, 0.404; CEA, 0.549; CA19-9, 0.568). The gene discussed is CEACAM5; the disease is neoplasm.