To demonstrate whether miR6778-5p regulates the multiplication of GC cells low-expressing Drosha, we transfected Drosha low-expressing GC cells (MGC-803/Drosha KD and SGC-7901/Drosha KD) with miR6778-5p mimics and evaluated the proliferation potential change of MGC-803/Drosha KD and SGC-7901/Drosha KD treated with miR6778-5p mimics. This evidence concerns the gene DROSHA and gastric cancer.