In a multicenter European cohort of CNS patients with NPHS1 mutations there was also no significant difference in the rates of peritonitis (32 and 13%), central line infections (48 and 47%), or sepsis (54 and 53%) between 17 patients managed conservatively and 25 patients with bilateral nephrectomy, 2.8 years after diagnosis (19, 20). This evidence concerns the gene NPHS1 and Sepsis.