Ginsenoside Rb1 inhibited mitochondrial dysfunction by reducing Bax and Cleaved Caspase-3 levels and upregulating Bcl-2 levels in the hippocampus with Aβ1-40 induced AD rats, thereby inhibiting neuronal apoptosis and improving learning and memory abilities of rats in spatial navigation (Wang et al., 2018). This evidence concerns the gene BCL2 and Alzheimer disease.