CASP3 and Alzheimer disease: Ginsenoside Rb1 inhibited mitochondrial dysfunction by reducing Bax and Cleaved Caspase-3 levels and upregulating Bcl-2 levels in the hippocampus with Aβ1-40 induced AD rats, thereby inhibiting neuronal apoptosis and improving learning and memory abilities of rats in spatial navigation (Wang et al., 2018).