E2F1 and colorectal carcinoma: Lan et al. (2021)investigated the transcriptome-level mechanisms of baicalin-mediated anti-tumor effects on osteosarcoma (OS) and identified 58 lncRNAs and 31 miRNAs that responded to the treatment. In addition, baicalin can suppress the malignant phenotypes of CRC by regulating the circRNA MYH89/miR-761 axis (Zhang et al., 2021). Based on high-throughput sequencing, Cheng et al. (2021) found that the herbal ingredient apigenin (API) suppressed CRC cell proliferation by decreasing E2F1/3 and regulating miRNA-215-5p.