Transcriptomics and metabolomics assays showed that the Chinese herbal Shuanghua Baihe tablet (SBT) can alleviate chemotherapy-induced OM in colon cancer patients by regulating linoleic acid metabolism, glycerophospholipid metabolism, and amino acid metabolism, as well as by inhibiting IL-17/TNF signal transduction to restore Treg and Th17 cell homeostasis in OM rats (Geng et al., 2021). This evidence concerns the gene TNF and ocular melanoma.