GRM1 and GRM5 are type I metabotropic glutamate receptors involved in various mental illnesses, including depression, anxiety, and cognitive impairment by regulating the function of neurotransmitters such as glutamate, dopamine, and norepinephrine (Pittaluga, 2016; Borbely et al., 2022). This evidence concerns the gene GRM5 and major depressive disorder.