Luteolin is a flavonoid found in many herbal extracts with antioxidant, anti-inflammatory and anti-tumor activities, and has been shown to reduce glucocorticoid-induced osteoporosis by modulating the ERK/Lrp-5/GSK-3β signaling pathway in vitro and in vivo (Jing et al., 2019). This evidence concerns the gene LRP5 and osteoporosis.