The activation of MAPK can activate the downstream “peroxisome proliferators-activated receptor gamma” (PPARγ) to induce the apoptosis of vascular smooth muscle cells (Wan et al., 2014), and inactivation of the MAPK/PPARγ signaling alleviates diabetes-induced ED via suppression of the corpus cavernosal cell apoptosis (Zhang Z. et al., 2019). Here, PPARG is linked to diabetes mellitus.