In a randomized control clinical trial, after 3 months of treatment with Qianlieshutong capsule combined with α-Lipoic acid, it could significantly improve erectile function in DM patients via upregulating NO, superoxide dismutase (SOD), and glutathione peroxidase (GSH) and downregulating homocysteine, MDA, and ET-1, compared with the patients treated only with α-Lipoic acid (Guo, 2016). Here, EDN1 is linked to diabetes mellitus.