The characterization of endometriosis-specific exosomes such as miR-214-3p (Zhang et al., 2021a), extracellular vesicular Legumain pseudogene 1 (EV-LGMNP1) (Sun et al., 2022) and actin filament associated protein 1-antisense RNA 1 (AFAP1-AS1) (Wang et al., 2022b) could open up new diagnostic and investigative pathways for treating endometriosis (Nazri et al., 2020). Here, PTGDR is linked to endometriosis.