Using a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (PMTP) induced mouse PD model to evaluate the neuroprotective effect of V. wallichii, the results showed that the 50% methanol extract of V. wallichii upregulated the levels of dopamine and tyrosine hydroxylase, increased the number of midbrain tyrosine hydroxylase positive cells, enhanced antioxidant activity, reduced reactive oxygen species (ROS), lipid peroxidation (LPO), and inflammatory cytokines (Subhashree et al., 2015). This evidence concerns the gene TH and Parkinson disease.