XDH and myocardial ischemia: Another study showed that the protective effect of V. officinalis on myocardial ischemia–reperfusion injury might occur through inhibiting xanthine oxidase, reducing the production of free radicals, increasing the value of prostacyclin 2/thromboxane A2, inhibiting platelet aggregation, improving coronary microcirculation, decreasing TNF-α production, and reducing aseptic inflammation in the reperfusion area to alleviate myocardial ischemia–reperfusion injury (Yin et al., 2000).