CD4 and Opportunistic infection: Because when you really think about it, we come a long way with the management of HIV patients, before we used to initiate people with CD4 count of 200 and guidelines improved and said we must initiate people with 350, it then went to 500, now we initiate everyone who is tested HIV positive, I think this is a success because we do not have to wait for someone to have a low CD4 count and possibly opportunistic infections... .