The high correlation between sedentary and standing time may suggest that these behaviours are likely to displace each other, which may be why the observed links between sedentary time and standing time with RA outcomes were of similar effect sizes in path models (e.g., sedentary time → CRP, β = 0.38; standing time → CRP, β = − 0.40). The gene discussed is CRP; the disease is rheumatoid arthritis.