To investigate the role of YAP1 in colitis-associated carcinogenesis and progression upon CXCL12/CXCR7 biased activation in vivo, wild type (WT) and Villin-CXCR7 transgenic mice (Villin-CXCR7) were treated with AOM and DSS for 3 cycles as described in methods. The gene discussed is CXCL12; the disease is infectious otitis media.