Chemokine CXC motif receptor 4 (CXCR4) has long been thought to be the unique receptor for Chemokine CXC motif ligand 12 (CXCL12) and play important roles in chemotaxis, inflammation, cancer dissemination and organotropic liver metastasis of colorectal cancer (CRC). This evidence concerns the gene CXCL12 and colorectal carcinoma.