To further prove that YAP1 is involved in the regulation of CXCR7-induced EMT, CRC cells overexpressing CXCR7 were transfected with siYAP1, as a result, knockdown of YAP1 significantly suppressed the upregulation of Vimentin and DCLK1 induced by overexpression of CXCR7 (Fig. 3H, I). This evidence concerns the gene ACKR3 and colorectal carcinoma.