The relative mRNA expression level of phosphoenolpyruvate carboxykinase (PEPCK) was significantly increased in the hypothalamus of STZ-treated animals to 14.58 (± 2.52) compared to the expression level of the control, which was considered as 1, showing disturbance in the gluconeogenesis, which is a sign of diabetes mellitus. Here, PCK2 is linked to diabetes mellitus.