CRP and infection: According to the pediatric guidelines of antibiotic choice in our institute, all our patients received the first line of antibiotics including (amoxicillin/clavulonate-ampicillin/sulbactam-amikacin–gentamycin-cefotaxime); meanwhile, 94% (47/50) of patients were shifted to the second line which includes (ciprofloxacin-piperacillin/tazobactam–teicoplanin–vancomycin-imipenem) based on the indicators of infection (fever, high CRP, and shift to left).