,13 IL-1β and IL-18 are significantly elevated in patients with severe COVID-19, and positively correlate with adverse clinical outcomes.13, 14, 15 Accordingly, post-mortem analysis of lungs from patients with COVID-19-related ARDS has shown intense expression of active NLRP3 inflammasome.16 The gene discussed is NLRP3; the disease is acute respiratory distress syndrome.