The development of subcutaneous tumors from implanted KYSE510 cells silenced for LOXL2 expression was strongly inhibited, whereas re-expression of LOXL2 or L2Δ13 in the LOXL2-silenced cells partially restored tumor development (Fig. 1F and G; Supplementary Fig. S1E). The gene discussed is LOXL2; the disease is neoplasm.