LOXL2 and cancer: We silenced LOXL2 expression in esophageal cancer cells using specific siRNAs or shRNAs, and then conducted rescue experiments by ectopically re-expressing full-length LOXL2 or L2Δ13 in the LOXL2-silenced cancer cells as previously described (Fig. 1A; Supplementary Fig. S1A) [16].