TNF and obesity due to melanocortin 4 receptor deficiency: Our previous study has shown that visceral adipose tissue‐derived macrophages (ATMs) causing obesity‐induced inflammation by releasing inflammatory cytokines such as tumor necrosis factor‐alpha (TNF‐α) and interleukin‐6 (IL‐6) overexpress prohibitin on its surface.[42] Also, it has been reported that HO‐1 upregulation in macrophages ameliorates inflammation and switches its phenotype into anti‐inflammatory M2 types.[28] ATMs were isolated from visceral adipose tissue of high‐fat diet‐induced type 2 diabetic mice.