Finally, immunofluorescence and H&E staining showed that lowered serum FFAs levels exhausted by brown adipose tissue and increased HO‐1 activity in the liver synergistically alleviated hepatic steatosis due to the reduction of hepatic ballooning and hepatic lipid accumulation in PBP‐NPs injected mice (Figure 7d). This evidence concerns the gene HMOX1 and fatty liver disease.