ATM and adipocytes have been known to crosstalk and differentiate to induce inflammation in obese adipose tissue, which develops into obesity‐induced metabolic syndrome.[45] To evaluate the dual targeting effects of PBP‐NPs on ATM and adipocytes, the direct co‐culture system mimicking adipose tissue environment was used. This evidence concerns the gene ATM and obesity due to melanocortin 4 receptor deficiency.