This family has been found to have multiple roles in tumor development, and family member TM4SF1 has been reported to play an important role in a variety of tumors including lung [18], prostate [9], breast [19], liver [20, 21], bladder [22], and pancreatic cancers [11, 13, 23]. The gene discussed is TM4SF1; the disease is familial pancreatic carcinoma.