After we analyzed the correlation between TM4SF18 expression and TMB in different tumors, we found that TM4SF18 expression in adrenocortical carcinoma, cervical squamous cell carcinoma and endocervical adenocarcinoma, HNSC, KICH, brain lower‐grade glioma, liver hepatocellular carcinoma, lung adenocarcinoma, LUSC, ovarian serous cystadenocarcinoma, pancreatic adenocarcinoma, STAD, thyroid carcinoma, and thymoma was significantly correlated with TMB (P < 0.05) (Fig. 8D). The gene discussed is TM4SF18; the disease is lung adenocarcinoma.