Multivariate Cox regression analysis further revealed that the factors affecting the survival of GC patients included age (P < 0.001, HR = 1.039), gender (P = 0.091, HR = 1.443), grade stage (P = 0.088, HR = 1.397), and TM4SF18 expression level (P = 0.045, HR = 1.290) (Fig. 4B, Table 3). Here, TM4SF18 is linked to gastric cancer.