Using gene-based association analysis in 1576 participants of the AD neuroimaging initiative (ADNI) phases 1, GO and 2, we identified genetic variants in the coding regions linked to seven of the 35 genes in the SM pathway to be significantly associated with AD and its (bio)markers, which covered the whole spectrum of Amyloid, Tau, Neurodegeneration, Cognition (A-T-N-C) measures47 (Supplementary Table 3). The gene discussed is MAPT; the disease is Alzheimer disease.