SPTLC3 was associated with cognitive performance (corrected p-value = 0.02; Fig. 3a), brain atrophy in focal regions of the bilateral temporal and frontal lobes (determined by detailed surface-based whole-brain analysis of cortical thickness measured from MRI scans on a vertex-wise level; colored regions with corrected p-value < 0.05; Fig. 3b) and FDG-PET measures in the bilateral temporal and parietal lobes (colored regions with corrected p-value < 0.05; Fig. 3c). Here, SPTLC3 is linked to Brain atrophy.