Consensus clustering of all PDAC, cholangiocarcinoma, and colorectal adenocarcinoma samples based on the expression of the KRAS mutation status signature genes (genes conservatively DE in KRAS wildtype vs. mutant mPDAC; n = 227) revealed an optimal solution based on four clusters (Fig. 5 and Supplementary Fig. 9). Here, KRAS is linked to cholangiocarcinoma.