By leveraging additional sequencing data from metastatic colorectal adenocarcinoma and cholangiocarcinoma cancer types as well as two independent cohorts of mPDAC samples, we highlight results indicative of roles of transcription factors NR5A2 and PROX1 in KRAS wildtype mPDAC as well as a distinct similarity between cholangiocarcinoma and KRAS wildtype mPDAC samples. This evidence concerns the gene NR5A2 and cholangiocarcinoma.