We proved that the knockdown of HIF-1α or HIF-2α both significantly suppressed the GBM cell death (Fig. 7C) and increase of cellular iron (Fig. 7D) as well as inhibited upregulation of the hallmark genes (Fig. 8B), suggesting that both HIF-1α and HIF-2α activation contributed to the ferroptosis induction. This evidence concerns the gene HIF1A and glioblastoma.