Reduced acetylation levels of histone H3 and H4 have been suggested to be associated with p21 downregulation and GC progression.531,532 Additionally, dysregulation of histone methylation and acetylation is involved in the progression and EMT of GC by cooperative regulation with PI3K/AKT and Wnt signaling pathways.533,534. This evidence concerns the gene CDKN1A and gastric cancer.