Other in vitro studies have indicated that ETS homologous factor (EHF) may be critical to GC cell proliferation, apoptosis, cell cycle, EMT, and invasion via the activated c-Met pathway,258 whereas IL-10 secreted by cancer-associated macrophages (CAMs) may be involved in GC carcinogenesis.259 Nevertheless, the clinical significance of miRNAs, EHF, and IL-10 in GC diagnosis and treatment must be further verified. This evidence concerns the gene IL10 and cancer.