ERBB2 and cancer: For instance, in several HER2-induced cancers, the HER2/HER3 dimer, the most potent EGFR family heterodimer, is indispensable for tumorigenesis and tumor maintenance.120 Therefore, restricting the dimerization of HER2 with other EGFR family members, particularly HER3, might provide an efficient treatment strategy for HER2-positive tumors.