Natural drugs targeting NF-κB have exhibited potential as chemotherapy for GC.334–337 For example, Ji and colleagues have reported that tetramethylpyraz, a natural alkaloid, induces GC cell apoptosis by downregulating NF-κB and cyclin D1.338 Therefore, screening chemotherapeutic drugs with NF-κB-targeting effects may be a potential strategy for improving chemotherapy. The gene discussed is CCND1; the disease is gastric cancer.