Further analysis in clinical samples also revealed a positive correlation between the CXCL12 receptor CXCR4 and c-MET phosphorylation as well as poor patient prognosis, indicating the clinical importance of the crosstalk between c-MET and CXCL12 in GC treatment.253 Several miRNAs have been reported to be involved in GC proliferation and metastasis by their regulation of HGF/c-MET expression. The gene discussed is CXCL12; the disease is gastric cancer.