The JAK dimers mediate phosphorylation of tyrosine 705 of STAT3, and the activated STAT3 is released from the kinase complex and subsequently translocates into the nucleus.441 As a transcriptional factor, nuclear STAT3 regulates the gene expression of a wide range of genes that are involved in promoting cancer cell growth, tumor invasion, and chemoresistance.442,443 The STAT3 pathway is significantly involved in the tumor progression and metastasis of GC. This evidence concerns the gene STAT3 and neoplasm.