CDH1 and gastric cancer: E-cadherin also plays vital roles in signaling pathways that regulate cell survival, proliferation, migration, and invasion.24,25 The link between the CDH1 gene mutation and the diffuse type of GC was first identified in a large Aboriginal family in New Zealand in 1998 by Guilford and colleagues.26 Molecular genetic testing for the CDH1 gene mutation is a recommended approach for confirming the diagnosis and family studies of HDGC.27