Proto-oncogene mutation affects upstream factors of the NF-κB signaling pathway, and these factors activate the NF-κB signaling pathway and downstream effectors and initiate gastric carcinogenesis.319 Uncontrolled NF-κB signals lead to the occurrence of many tumors, and the abnormal activation of NF-κB in tumors may be one of the main anti-apoptotic factors in GC cells.319,320 When activated, it can generate strong anti-apoptotic signals and accelerate tumor development. Here, NFKB1 is linked to neoplasm.