H. pylori infection can promote the accumulation of mutations in the TP53 gene, which has been reported to occur in 50% of gastric tumors.216 The proteasomal degradation of p53 may also be induced indirectly by H. pylori infection.217,218 In response to genotoxic stress, p53 triggers signaling pathways that lead to temporary cell cycle arrest, activating the repair process of DNA.219 Inactivation of p53 promotes genomic instability, which is a hallmark of cancer.220 Thus, inhibition of p53 can be a strategy for modulating host cell function in response to H. pylori. This evidence concerns the gene TP53 and gastric neoplasm.