Long et al.424 and Jiang et al.425 reported that low expression of galectin-9 in GC patients was associated with poor survival, whereas the study from Wang et al.374 reported that galectin-9 expression negatively correlated with poor prognosis in GC patients.374 This discrepancy may occur because of differing functions of galectin-9 in different immune states of the patients. The gene discussed is LGALS9; the disease is gastric cancer.