Zhao et al. found that HIF-1α/miR-17-5p axis may contribute to the tumor growth and metastasis of GC by negatively regulating programmed cell death 4 (PDCD4).461 On the other hand, dysregulated miR-27a,462 miR-421,463 and lncRNA-PVT1464 may be associated with HIF-1α-mediated cisplatin resistance in GC. The gene discussed is HIF1A; the disease is gastric cancer.