STAT3 signaling was reported to drive EZH2 epigenetic modification, which is associated with advanced TNM stage and poor prognosis.444 Analysis of patient samples revealed that increased survivin and STAT3 expression significantly correlated with concurrent H. pylori infection; moreover, their subcellular localizations are key factors influencing GC progression.445 Therefore, STAT3 and survivin expressions can be collectively used as potential prognostic biomarkers and therapeutic targets for GC. This evidence concerns the gene BIRC5 and gastric cancer.