For instance, hypermethylation of the DKK3 gene, which is an inhibitory regulator of β-catenin, is commonly found in GC patients inducing activation of Wnt/β-catenin and poor survival.527 Hypermethylation of the tumor suppressor gene ADAMTS9 in GC associates with abnormal activation of the AKT/mTOR pathway and cancer progression.528. This evidence concerns the gene DKK3 and gastric cancer.