The phosphoinositide 3-kinase (PI3K) pathway plays a key role in the proliferation and survival of various cancer cells including GC.135–137 The PI3K/AKT/mTOR signaling pathway promotes tumor progression in GC through several mechanisms, including the inhibition of apoptosis, induction of drug resistance, metastasis, and angiogenesis138 (Fig. 2). Here, AKT1 is linked to gastric cancer.