Its abnormal activation is involved in direct intercellular communication and plays an essential role in the formation, development, survival, proliferation, invasion, and metastasis of tumors.481,482 Notch signaling activation is associated with various cancers and was recently established as a critical pathway regulating gastric stem cell proliferation and differentiation.483 Notch induces excessive cell proliferation by upregulating the expression of nuclear transcription factor NF-κB.484 It also promotes epithelial cell proliferation and participates in gastric mucosal carcinogenesis. This evidence concerns the gene NFKB1 and cancer.