LGALS3 and gastric cancer: LAG-3 expression has a remarkable synergistic effect with PD-1 on promoting the immune escape of GC cells, which suggests it might be a biomarker of poor prognosis.369 Galectin-3, the ligand of the LAG-3 inhibitory pathway, was also found to be a potential indicator for poor prognosis in the diffuse type of GC.