This results in p53 stabilization and transient cell cycle arrest.225,226 In about half of GC patients, USF1 expression is lower in tumor tissue than non-tumor tissue, and 88% of patients with low USF1 expression have H. pylori infection.227 Low expression of p53 closely correlates to low expression of USF1, and low expression of both is associated with poor prognosis.227. The gene discussed is TP53; the disease is gastric cancer.