HGF and gastric cancer: It has been reported that miR-1/34a/144/206 directly target the mRNA of c-MET.254–257 In contrast, miR-15a/16/195 are found to directly target HGF mRNA.258 These are negative regulators of HGF/c-MET expression, which are found down-regulated in GC tumors, implying their potential therapeutic applications to repress HGF/c-MET-mediated cell proliferation and migration in GC.