However, its utility as a prognostic marker may be population-dependent, since overexpression of galectin-3 was highly significant in the North American cohort but not in the Asian cohort.429 Targeting both LAG-3 and PD-1 has become an important cancer immunotherapy strategy.372,430 However, the understanding of LAG-3’s mechanism in GC is still minimal, and many fundamental questions remain unanswered. The gene discussed is LGALS3; the disease is gastric cancer.