STAT3 and neoplasm: Due to the influence of hypoxia and high pressure in tumor microenvironment, pathological metabolic disorder occurs in adipocytes, which changes the secretion of adipokines and lipid metabolites around tumor cells, activates signal transducer and activator of transcription 3 (STAT3) and other tumor-related signaling pathways, and accelerates the further development and deterioration of tumor [69].