C1-2 cells lacked reported cancer cell functional alterations (Additional file 9: Fig. S2C), suggesting that they are enriched in normal epithelial cells (Fig. 3D), and C1 cells expressed markers of mature colonocytes (GUCA2B, SLC26A3 and CA1) (Additional file 9: Fig. S2D). The gene discussed is GUCA2B; the disease is cancer.