FOXO3 and cancer: LAMB3 has been reported to play a protumorigenic role in CRC through the AKT-FOXO3/4 axis [44].ERO1A has been reported to be an unfavorable factor in multiple cancers, including pancreatic cancer [45] and breast cancer, [46] with a cancer-promoting effect in HCT116 CRC cells by regulating integrin-β1.