CD4 and colorectal carcinoma: To decipher the cellular composition of CRC in a larger population, we employed the newly developed deconvolution tool CIBERSORTx [27].Signature templates derived from the SMC cohort were created with simplified T-cell subgroups: CD4+ T cells, Treg cells, CD8 + T cells, TEX cells and ILCs (Fig. 2A, Additional file 4: Table S4).