PTK2 and metabolic dysfunction-associated steatohepatitis: FAKHepKO mice and FAKflox mice were injected with/without LV-shDUSP22 vector through the portal vein to construct hepatocyte-specific DUSP22-FAK loss-of-function mice or hepatocyte-specific FAK loss-of-function mice before 24 weeks of NASH diet feeding (FAKHepKO/HFHC) or halfway by NASH diet feeding (FAKHepKO/LV-shDUSP22/HFHC, FAKflox/LV-shDUSP22/HFHC) (Supplementary Fig. 22a).