Among all these analyzed DUSPs, DUSP3, DUSP8, DUSP12, DUSP14, DUSP16, DUSP22, and DUSP26 were significantly decreased in the liver of NASH patients with obvious hepatocyte ballooning, severe inflammatory infiltrate, and pattern of liver fibrosis compared with the normal individuals. Here, DUSP16 is linked to metabolic dysfunction-associated steatohepatitis.