DUSP22 and metabolic dysfunction-associated steatohepatitis: Due to the different mechanisms and pathogenesis of NASH progression caused by a high-fat diet plus methionine- and choline-deficient diet (HFMCD) and other high-energy diets (i.e., HFHC), we subsequently investigated if DUSP22 also exerted protective effects against an 8-week HFMCD-triggered NASH in DUSP22HepKO and DUSP22HepOE mice (Supplementary Fig. 14a and b).