INS and metabolic dysfunction-associated steatohepatitis: In the ex vivo transplanted mouse model, hepatocyte-specific DUSP22 overexpression (LV-DUSP22) transduction dramatically reduced liver weight, LW/BW ratio, blood glucose concentrations, fasting insulin levels, HOMA-IR values, and serum concentrations of ALT and AST in mice with a 24-week HFHC challenge; however, hepatocyte-specific DUSP22 knockdown (LV-shDUSP22) mice exhibited remarkably accelerated NASH phenotypes caused by HFHC, while no significant difference was observed in the body weight changes of all groups of mice (Fig. 7b–h).