According to our current findings, previous studies, and the characteristic of DUSPs family, we demonstrated that the dephosphorylating capacity of DUSPs family members (DUSP22, DUSP3, DUSP9, DUSP12, DUSP14, DUSP26, etc) might be indispensable for its protective role against hepatic steatosis. Here, DUSP22 is linked to fatty liver disease.