Additionally, compared with DUSP3, DUSP8, DUSP12, DUSP14, DUSP16, and DUSP26, hepatic DUSP22 protein expression levels showed a closer negative correlation with the body mass index (BMI), serum total cholesterol (TC), γ-glutamyl Transpeptidase (GGT), fasting blood glucose, alkaline phosphatase (AKP), collagen Type IV (IVC), and laminin (LN) contents, and liver IL-6 gene expression in NASH patients (Supplementary Fig. 2a–f and Supplementary Fig. 3a–h). This evidence concerns the gene DUSP3 and metabolic dysfunction-associated steatohepatitis.