Among all these analyzed DUSPs, DUSP3, DUSP8, DUSP12, DUSP14, DUSP16, DUSP22, and DUSP26 were significantly decreased in the liver of NASH patients with obvious hepatocyte ballooning, severe inflammatory infiltrate, and pattern of liver fibrosis compared with the normal individuals. This evidence concerns the gene DUSP14 and Hepatic fibrosis.