According to our current findings, previous studies, and the characteristic of DUSPs family, we demonstrated that the dephosphorylating capacity of DUSPs family members (DUSP22, DUSP3, DUSP9, DUSP12, DUSP14, DUSP26, etc) might be indispensable for its protective role against hepatic steatosis. The gene discussed is DUSP3; the disease is fatty liver disease.