DUSP22 and metabolic dysfunction-associated steatohepatitis: Meanwhile, ΔPTP-motif ablation remarkably abolished the protective function of DUSP22 on NASH in mice, as proved by the restrengthened hepatocyte ballooning, NAS score, lipid deposition, collagen accumulation, and CD11b-positive inflammatory cell infiltration in the liver of HFHC-fed mice (Supplementary Fig. 20g–l).