In vitro investigation indicated that upregulation of ARG2 in bovine retinal ECs induces mitochondrial dysfunction and fragmentation, increases EC stress, and reduces cell survival, ultimately promoting IR-induced vascular injury, while the specific knockdown of ARG2 in EC of IR mice model with injury in the right eye attenuates IR-induced retinal detachment/edema and reduces impairment of the blood-retinal barrier [56]. Here, ARG2 is linked to retinal detachment.