PLEKHH2 and neoplasm: As summarized in Supplementary Table 1, tumors with increased PLEKHH2 expression tended to display more malignant phenotypes such as lower differentiation (P = 0.001), greater clinical tumor size (P = 0.002), higher tumor node metastasis (TNM) stage (P = 0.013), and positive lymphatic metastasis (P = 0.002).