NOS3 and posterior cortical atrophy: In this context, considering a strong and positive correlation between NOS3 and the CSF1-CSF1R axis and based on findings that suggest that neo-adjuvant CSF1R inhibition is minimally effective against high-grade PCa [40], we hypothesize that increased oxidation because of uncoupling of NOS3 could reduce the efficiency of CSF1R blockade.