Moreover, the cytokine array showed a minimal impact of CSF1R blockade on several tumor-promoting cytokines such as ENA-78, BLC, IP-10, Oncostatin M, FGF-6, IGFBP-3, RANTES, Osteopontin, GCP-2, IL-15, MCP-4, NT-4, TGF- b 3, IL-3, SCF, IL12-p40, IGFBP-4, FGF-4, SDF-1, PDGF-BB, IL-1beta, PARC, TPO, IFN-gamma, FGF-7, and IL-2 respectively (Supplementary Fig. 3C). This evidence concerns the gene IGFBP3 and neoplasm.