EGFR exon 20 insertion (EGFRex20ins) is clustered between codons 762–775, such as A767_V769dup (V769_D770insASV) and S768_D770dup (D770_N771insSVD) [38, 39]; it represents approximately 6 ~ 12% of EGFR mutations in NSCLC cases [40–43] and frequently leads to the constitutive activation of EGFR [38]. This evidence concerns the gene EGFR and non-small cell lung carcinoma.