TNF and neoplasm: Moreover, further investigation of the tumor tissues demonstrated that DETA-Dex treatment markedly promoted T-cell-mediated antitumor immunity, as evidenced by the elevated levels of the cytokines TNFα and IL12, more CD4+ T cells infiltration into the tumor tissue (Fig. 5g and h), more Th1, Th2, and Th17 cells, and fewer Treg cells.