In particular, IFNγ can abolish venetoclax cytotoxicity via the JAK-Src/STAT3/Mcl-1 pathway, whereby this leads to upregulation of Mcl-1 in CLL cells [14], which is a well know resistance mechanism of CLL cells to venetoclax [17, 18]. This evidence concerns the gene STAT3 and B-cell chronic lymphocytic leukemia.