In this two-sample MR study, we expanded the analysis to include seven other sex steroid hormones as well as investigating the effect of the hormones on subtype-specific BC risk (luminal A-like BC, luminal B-like BC, luminal B/HER2-negative-like BC, HER2-enriched-like BC, TNBC and BRCA1 mutated TNBC). The gene discussed is BRCA1; the disease is breast cancer.