Similar to TT, BT and estradiol, we found a positive association between an SD increase in DHEAS (proxied by 4 SNPs) and ER + BC risk (OR 1.09, 95% CI 1.03–1.16), with positive associations also observed using the weighted median, weighted mode and MR-Egger approaches (OR 1.08, 95% CI 1.04–1.13, OR 1.08, 95% CI 1.03–1.13, OR 1.07, 95% CI 0.97–1.18, respectively) (Additional file 1: Table S3). The gene discussed is SULT2A1; the disease is breast cancer.