We also found positive associations between an SD increase in DHEAS and luminal A-like BC, luminal B-like BC and luminal B/HER2-negative-like BC (OR 1.06, 95% CI 1.02–1.11, OR 1.11, 95% CI 1.00–1.22 and OR 1.09, 95% CI 1.01–1.19, respectively) and found concurring results with the weighted median approach for all subtypes and suggestive positive associations for both the weighted mode and MR-Egger approaches (Additional file 1: Table S3). The gene discussed is ERBB2; the disease is breast cancer.