Functional studies in NSCLC cell lines and genetically engineered lung cancer mouse models of CREB-regulated transcription coactivators support the tumor-promoting role of CREB-mediated transcriptional activation in NSCLC [11–13]. Previous studies have reported that the PKA-CREB axis has tumor-promoting effects in lung cancer [14, 15]. This evidence concerns the gene CREB1 and neoplasm.