CREB1 and neoplasm: The present study aimed to investigate the efficacy of a novel diarylcyclohexanone derivative, MHY4571, in regulating the PKA-CREB pathway and to study its anti-tumor role in squamous NSCLC. In addition, we also sought to evaluate the synergetic effects of MHY4571 and cisplatin on cell viability in squamous cell lung cancer cell lines.