Since 2015, several CardioVascular Outcomes Trials (CVOTs) have demonstrated that sodium-glucose cotransporter-2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP-1 RA) provided significant cardiorenal benefits, compared with placebo, for patients with T2D [5–11]. This evidence concerns the gene GLP1R and type 2 diabetes mellitus.