GLP1R and type 2 diabetes mellitus: Based on these studies, there has been a paradigm shift in national and international T2D treatment guidelines; SGLT2i or GLP-1 RA are recommended either as first-line therapy or after metformin for patients with atherosclerotic CVD or at high CV risk, while SGLT2i is preferred after metformin for patients with heart failure or CKD [24, 25].