CD19 and diffuse large B-cell lymphoma: Yescarta (Axicabtagene Ciloleucel, KTE-X19), the second generation of retroviral-transduced CD-28 based CAR-T cell product (CD19/FMC63), was approved by FDA on October 18, 2017 for the treatment of adult patients with R/R LBCL after two or more lines of systemic therapy, including DLBCL, primary mediastinal B-cell lymphoma (PMBCL), HGBCL and transformed follicular lymphoma (TFL) [69].