Additionally, chemo-antibiotic drugs like daunorubicin, actinomycin D, doxorubicin (DOX), and epirubicin were found to increase the expression of GSDMC and nuclear PD-L1 in breast cancer, which further promoted caspase-3/8-mediated pathway and ultimately led to pyroptosis [92, 93]. The gene discussed is CD274; the disease is breast cancer.