As a member of natural flavonoids, galangin exerts a vital role in suppressing tumor growth and reducing cell viability of glioblastoma cells by triggering GSDME-dependent pyroptosis [67], while anthocyanin promotes the cell death of oral squamous cell carcinoma (OSCC) via activation of GSDMD-dependent pyroptosis [68]. This evidence concerns the gene GSDMD and neoplasm.