GSDME and congenital rubella syndrome: A study by Liu et al. reported that upon incubation with CD19 + leukemic cells, CAR-T cells could increase the release of lactic dehydrogenase (LDH), and upregulate expression GSDME and IL-1β, suggesting that CAR-T cells can activate GSDME-mediated pyroptosis by releasing a large amount of perforin and GzmB, and could ultimately result in CRS [94].