In addition, the results of KEGG pathway analysis corresponding to 351 genes related to renal insufficiency including cytokine-cytokine receptor interaction [40], AGE-RAGE signaling pathways in diabetic complications [41], PI3K-Akt signaling pathway [42], HIF-1 signaling pathway [42], metabolic pathways [43], proteoglycans in cancer [44], transcriptional misregulation in cancer [45], fluid shear stress and atherosclerosis [46] and Human cytomegalovirus infection [47]. The gene discussed is AKT1; the disease is Renal insufficiency.