In conclusion, we identified 26 core genes, CST3, SERPINA1, FN1, PF4, IGF1, KNG1, IL6, VEGFA, ALB, TIMP1, TGFB1, HGF, SERPINE1, APOA1, APOB, FGF23, EGF, APOE, VWF, TF, CP, GAS6, APP, IGFBP3, P4HB, and SPP1, that may be related to renal insufficiency in patients with geriatric multimorbidity. Here, APOA1 is linked to Renal insufficiency.