In conclusion, we identified 26 core genes, CST3, SERPINA1, FN1, PF4, IGF1, KNG1, IL6, VEGFA, ALB, TIMP1, TGFB1, HGF, SERPINE1, APOA1, APOB, FGF23, EGF, APOE, VWF, TF, CP, GAS6, APP, IGFBP3, P4HB, and SPP1, that may be related to renal insufficiency in patients with geriatric multimorbidity. This evidence concerns the gene CP and Renal insufficiency.