Table 2 shows that most of the important signaling pathways that were enriched were "pathways in cancer" (P = 2.40582E−63), "cytokine-cytokine receptor interaction" (P = 9.03679E−52), "AGE-RAGE signaling pathways in diabetic complications" (P = 1.20609E−43), "PI3K-Akt signaling pathway" (P = 1.90881E−39) and "HIF-1 signaling pathway " (P = 6.07415E−36) involved 58, 39, 29, 36 and 25 TMGs, respectively (Table 2). This evidence concerns the gene RENBP and cancer.