Currently, there are few studies on the direct relationship between APP, CP, EGF, GAS6, HGF, IGF1, IGFBP3, KNG1, SERPINE1, SERPINA1, TF, PF4 and P4HB, and renal insufficiency in relevant literature, which can provide a reference for future studies on renal insufficiency with geriatric multimorbidity patients. The gene discussed is IGFBP3; the disease is Renal insufficiency.