In conclusion, we identified 26 core genes, CST3, SERPINA1, FN1, PF4, IGF1, KNG1, IL6, VEGFA, ALB, TIMP1, TGFB1, HGF, SERPINE1, APOA1, APOB, FGF23, EGF, APOE, VWF, TF, CP, GAS6, APP, IGFBP3, P4HB, and SPP1, that may be related to renal insufficiency in patients with geriatric multimorbidity. The gene discussed is EGF; the disease is Renal insufficiency.